the methylation status of mgmt and sfrp2 genes in iranian patients with polyps
نویسندگان
چکیده
results methylation in at least one gene was reported about 93.8%. the methylation of sfrp2 was reported in 39 out of the 48 subjects (81.2%) whereas methylation of mgmt was observed in 32 subjects (66.6%). conclusions the current study results showed that methylation of sfrp2 and mgmt play an important role in polyp formation. materials and methods forty eight tissue samples of polyp and adenoma, and 20 control samples were investigated for methylation status of sfrp2 and mgmt with mutagenically separated polymerase chain reaction (ms-pcr) method. objectives due to correlation of polyp and cancer, the current study aimed to evaluate the role of sfrp2 and mgmt methylation in patients with polyp in south of iran. background colorectal cancer is the third most common cancer in the world and the forth cause of death by cancer globally. colorectal cancer starts with a polyp and might develop due to multiple epigenetic and genetic changes that lead to change of normal colon epithelium to adenocarcinoma of colon. recent studies show that epigenetic changes such as methylation of sfrp2 (secreted frizzled-related2) a gene in negative regulation wnt signaling pathways and mgmt (methylguanine-dna methyltransferase) a dna repair gene is associated with colorectal cancer.
منابع مشابه
the past hospitalization and its association with suicide attempts and ideation in patients with mdd and comparison with bmd (depressed type) group
چکیده ندارد.
study of sfrp1 and sfrp2 methylation status in patients with de novo acute myeloblastic leukemia.
intoduction: acute myeloid leukemia (aml) is a heterogeneous group of hematologic malignancies with abundant changeability in the pathogenesis. dna methylation of cpg islands within the promoters of specific genes may play roles in tumor initiation and progression. secreted frizzled-related proteins (sfrps) are negative regulator of the wnt signaling pathway. in the present study, we examined t...
متن کاملMethylation Status of SOX17 and RUNX3 Genes in Acute Leukemia
Background: Several studies have examined the presence of DNA methylation of CpG islands in leukemia. Methylation of SOX17 and RUNX3 genes may play a role in leukemogenesis through silencing tumor suppressor genes. We investigated the methylation status of SOX17 and RUNX3 genes in patients with acute leukemia. Methods: In this case-control study, peripheral blood samples from 100 AML and 10...
متن کاملefl students gender and socioeconomic status: the use of politeness strategies in the first and second languages
within the components of communicative competence, a special emphasis is put on the “rules of politeness,” specifically the politeness strategies (brown and levinson, 1978) that speakers deploy when performing the request speech act. this is because the degree of imposition that making a request places upon one’s interlocutor(s) has been seen to be influenced by several factors among which, as ...
the investigation of research articles in applied linguistics: convergence and divergence in iranian elt context
چکیده ندارد.
Study of SFRP1 and SFRP2 methylation status in patients with de novo Acute Myeloblastic Leukemia
INTODUCTION Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies with abundant changeability in the pathogenesis. DNA methylation of CpG islands within the promoters of specific genes may play roles in tumor initiation and progression. Secreted frizzled-related proteins (SFRPs) are negative regulator of the Wnt signaling pathway. In the present study, we examined th...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
thritaجلد ۴، شماره ۲، صفحات ۰-۰
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023